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Table 1 IC50 values for the inhibition by DPAB of the oxidation of selected aldehyde substrates by mouse and human ALDH1A1

From: 4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal

 

IC50 of DPAB (μM)

Substrate

ALDH1A1

 

Mouse

Human

all-trans Retinal

0.11 ± 0.02

0.13 ± 0.03

Propanal

0.040 ± 0.01

0.14 ± 0.04

Phenylacetaldehyde

0.36 ± 0.04

1.2 ± 0.1

  1. IC50 values are the mean ± average deviation from at least 3 spectrophotometric assays, each performed in triplicate.