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Figure 7 | BMC Pharmacology

Figure 7

From: The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution

Figure 7

Effect of RPR-130401 exposure on the chromosome number distribution in individual metaphases. HCT-116 cells were grown for 4-days without (A, B) or with 50 nM (C, D) or 500 nM (E, F) RPR-130401. Cells were then given 3.5 Gy γ-rays (B, D, F) and returned to the incubator for 24-h prior to fixation and scoring. Each panel represents the counts from at least 50 metaphases.

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BMC Pharmacology

ISSN: 1471-2210