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Figure 6 | BMC Pharmacology

Figure 6

From: The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution

Figure 6

Immunofluorescent visualization of cytoskeleton components in control (A, A', C) and treated (B, B', D) HCT-116 cells. Cells were grown on coverslips for 5-days without or with 500 nM RPR-130401. The cells were subsequently given 3.5 Gy γ-rays and allowed to rest in the incubator for 24-h. Cells were then fixed and incubated with TRITC-labeled phalloidin (A, B), or with an anti-α tubulin FTIC-conjugated antibody (C, D). Nuclei were counter-stained with bisbenzimide (A', B'). Cells were viewed as in Figure 5. The bar (C) represents 20 μm.

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