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Figure 3 | BMC Pharmacology

Figure 3

From: The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution

Figure 3

Effect of RPR-130401 on cell cycle progression. Cells were grown for a total of 5-days without or with 1 × IC50 or 10 × IC50 RPR-130401. At day 4, part of samples was irradiated to the dose indicated and allowed to rest in the incubator for an additional 24-h prior to harvest. The DNA content was determined from flow cytometric analysis of propidium iodide staining and BrdUrd incorporation. 104 nuclei were analysed for each sample. 2C, 4C and 8C, diploid, tetraploid and octoploid cells. Sq, quiescent (arrested in synthesis) S-phase cells.

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BMC Pharmacology

ISSN: 1471-2210