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Figure 3 | BMC Pharmacology

Figure 3

From: Does lindane (gamma-hexachlorocyclohexane) increase the rapid delayed rectifier outward K+ current (IKr) in frog atrial myocytes?

Figure 3

Effects of E-4031 on the lindane-induced outward current Membrane current was recorded on voltage-clamped frog atrial myocytes bathed in a control Ringer solution containing TTX (0.6 microM), Cd2+ (1 mM), TEA (10 mM) and Ba2+ (2 mM). A). Superimposed traces of the current elicited by a 170 mV depolarizing step potential applied from HP = -100 mV (c) before and after lindane (1.7 microM) application (traces a) and subsequent addition of E-4031 (1 microM) to the solution containing lindane (traces b); (white circle) control solution: (black circle) control solution containing lindane; (white square) control solution containing lindane and E-4031. B). Current-voltage relationships plotted for the outward current measured at the end (500 ms) of the clamp potential steps, HP = -100 mV. (white circles) control solution; (black circles) control solution containing lindane (1.7 microM); (white squares) control solution containing lindane and E-4031 (1 micro M).

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