Figure 2

Effects of lindane on frog atrial myocytes membrane current Membrane current was recorded on voltage-clamped frog atrial myocytes bathed in a control Ringer solution containing TTX (0.6 microM), Cd²⁺ (1 mM) and TEA (10 mM). A). Superimposed traces of the current (upper traces) elicited by a 170 mV depolarizing step potential applied from HP = -100 mV (lower trace). (white circle) control solution; (black circle) control solution containing lindane (1.7 microM) B). Current-voltage relationships plotted for the outward current measured at the end (500 ms) of the clamp potential steps, HP = -100 mV. (white circles) control solution; (black circles) control solution containing lindane (1.7 microM); (black triangles) control solution containing lindane and Sr²⁺ (5 mM); (black squares) control solution containing lindane, Sr²⁺ and quinidine (0.5 mM).