Skip to main content

Table 1 Growth rate of promastigotes and SbV susceptibility of intracellular amastigotes, of L. infantum strains, after repeated in vitro and in vivo passages and dogs treatment with meglumine antimoniate.

From: In vitro susceptibility to pentavalent antimony in Leishmania infantum strains is not modified during in vitro or in vivo passages but is modified after host treatment with meglumine antimoniate

Strain Code

Growtha

IC 50 (mg SbV/L)b

IC 50 Mean values

MCAN/ES/92/BCN 82

61

5.0 ± 0.2

Untreated animals

MCAN/ES/92/BCN 83

69

4.9 ± 0.2

4.7 ± 0.4

MCRI/ES/94/BCN 328

57

4.4 ± 0.1

 

MCAN/ES/95/BCN 335

24

6.7 ± 0.5

 

MCAN/ES/95/BCN 336

22

6.0 ± 0.2

Treated animals

MCAN/ES/98/BCN 323

29

9.7 ± 0.3

7.7 ± 1.5

MCAN/ES/98/BCN 329

31

9.1 ± 0.6

 

MCAN/ES/98/BCN 331

28

6.9 ± 0.5

 
  1. a: promastigotes × 106/mL Schneider's medium + 20% HIFCS, after three days of culture b: values are the means ± the standard deviation of three counts in two separate assays (n = 6)