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Table 2 Bronchoalveolar lavage inflammation in BALB/c mice 24 hours after the challenge with 0.3, 0.5 or 1 mg/kg of LPS.

From: In vivo models of lung neutrophil activation. Comparison of mice and hamsters

  PBS (50 μl) LPS (0.3 mg/kg) LPS (0.5 mg/kg) LPS (1 mg/kg)
Neutrophils (× 105 cells/ml) 0.66 ± 0.21 9.9 ± 1.1* 10.1 ± 0.8* 11.6 ± 2.4*
Macrophages (× 105 cells/ml) 1.65 ± 0.23 1.24 ± 0.4 1.43 ± 0.07 1.69 ± 0.21
Lymphocytes (× 105 cells/ml) 0.02 ± 0.01 0.10 ± 0.02* 0.06 ± 0.01* 0.10 ± 0.07*
Total cell counts (× 105 cells/ml) 2.34 ± 0.29 10.29 ± 1.09* 11.6 ± 0.8* 13.4 ± 2.6*
MPO (mU/ml) 41.2 ± 0.007 1045.5 ± 178.6* 1451.7 ± 123.4* 1235.8 ± 368.7*
Elastase (ng/ml) 0 ± 0 264.4 ± 21.9* 215.8 ± 8.5* 287.5 ± 21.4*
  1. Animals were intranasally challenged with 0.3, 0.5 or 1 mg/kg of LPS or PBS alone (50 μl). Twenty four hours after the challenge, animals were sacrificed and bronchoalveolar lavage performed. Data are expressed as mean ± SEM 6 mice per group. Significance, (P < 0.05) indicated by (*) is versus PBS-challenged mice.