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Table 1 Levels of bronchoalveolar lavage myeloperoxidase (MPO) activity, elastase activity and TNF-α following LPS challenge in BALB/c mice.

From: In vivo models of lung neutrophil activation. Comparison of mice and hamsters

  TNF-α 3 h (ng/ml) MPO 3 h (mU/ml) MPO 24 h (mU/ml) Elastase 24 h (ng/ml)
PBS (50 μl) 0 ± 0 5.1 ± 4.8 56.7 ± 7.2 0 ± 0
LPS (0.05 mg/kg) 4.5 ± 0.6* 4.5 ± 2.4 733.3 ± 103.4* 18.3 ± 1.23 *
LPS (0.1 mg/kg) 15.3 ± 1.2* 14.1 ± 8.3 961.8 ± 320.4* 62.5 ± 3.5*
LPS (0.3 mg/kg) 24.5 ± 1.45* 35.4 ± 5.2* 1209.8 ± 170.4 * 252.1 ± 18.5*
  1. Animals were intranasally challenged with increasing concentrations of LPS (0.05 to 0.3 mg/kg) or PBS alone (50 μl). Three or 24 hours after the challenge, animals were sacrificed and bronchoalveolar lavage performed. Data are expressed as mean ± SEM from two different experiments each included 6 mice per group. Significance, (P < 0.05) indicated by (*) is versus PBS-challenged mice