Figure 4

Bronchoalveolar differential cell counts following sequential application of LPS and fMLP in hamsters. Animals were intratracheally challenged with LPS (0.5 mg/kg intratracheally) or PBS (100 μl). Twenty four hours after, hamsters were intratracheally challenged with 0.25 mg/kg of fMLP or 100 μl of vehicle (1% DMSO in PBS). Two hours after the second challenge, animals were sacrificed and bronchoalveolar lavage performed. Data are expressed as mean ± SEM from 5–6 hamsters per group. Significance (P < 0.05), indicated by (*) or (#) is versus PBS-challenged/Vehicle-treated hamsters and LPS-challenged/Vehicle-treated hamsters, respectively.