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Figure 1 | BMC Pharmacology

Figure 1

From: Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA1 receptor signalling in rat brain cryosections without affecting global LPA degradation

Figure 1

The two enzymatic pathways generating inorganic phosphate (P i ) as a result of LPA degradation. In the LPA → MAG → G pathway, lipid phosphate phosphatases (LPPs) dephosphorylate LPA resulting in the generation of equimolar amounts of monoacylglycerol (MAG) and Pi. MAG is further hydrolyzed by monoglyceride lipase (MGL), resulting in cleavage of the acyl moiety and the formation of glycerol (G). In the LPA → GP → G pathway, lysophospholipases (LPLs) catalyze the deacylation of LPA with the concomitant formation of glycerophosphate (GP). GP can be further metabolized by GP phosphatase (GPase) activity thereby generating equimolar amounts of Pi and G.

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BMC Pharmacology

ISSN: 1471-2210