Figure 7
DIfferential mechanism of calcium current modulation by Glu and CHPG in cells expressing mGluR1a. A, Sample calcium current traces elicited with the voltage protocol shown (below) illustrating control and Glu (upper) or CHPG (lower) inhibited currents in cells expressing either mGluR5b (left) or mGluR1a (right). Inhibited traces shown in gray. Note that the Gq-mediated component of inhibition is not reversed by the depolarizing step, and is therefore similar in both “Pre” and “Post.” Scale bars represent 0.4 nA and 10 msec. B, Summary of the Gq-mediated, voltage independent component of inhibition (expressed as the Post/Pre inhibition ratio) for Glu and CHPG (paired measurements in each cell) from mGluR5 (left) and mGluR1 (right) expressing cells. Number of cells in each group shown in parentheses.