Figure 3From: The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potencyCHPG induces strong calcium current modulation in SCG neurons expressing mGluR1a and 1b. A, Time course and sample current traces (inset) illustrating the magnitude of calcium currents in a representative mGluR1a expressing SCG neuron and inhibition by various concentrations of CHPG and by 100 μM Glu, as indicated. Cells were held at −80 mV and current was elicited by a 25 msec step to +10 mV. Scale bars represent 0.5 nA and 10 msec. B, Dose response curves for CHPG in cells expressing mGluR1a (open circles) or mGluR1b (open diamonds, as indicated. For mGluR1a, n = 12 at all concentrations. For mGluR1b (30–3000 μM), n = 5, 6, 7 and 7, respectively.Back to article page