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Figure 1 | BMC Pharmacology

Figure 1

From: The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency

Figure 1

CHPG induces strong calcium current modulation in SCG neurons expressing mGluR5. A, Time course and sample current traces (inset) illustrating the magnitude of calcium currents in a representative SCG neuron and inhibition by various concentrations of CHPG and Glu, as indicated. Voltage protocol consisted of a 25 msec step to +10 mV from a holding potential of −80 mV. Scale bars in inset represent 1 nA and 10 msec. B, Average (±SEM) calcium current inhibition at a range of CHPG concentrations (for [CHPG] ranging from 10 μM to 3 mM, n = 6, 3, 8, 4, 11, and 7, respectively).

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BMC Pharmacology

ISSN: 1471-2210