BMC Pharmacology

Table 3 Mean permeation rates and efflux ratios in LLC-PK1-MDR1 cell monolayers

From: Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

			Nor-BNI	GNTI	JDTic	Naltrexone	Loperamide
P_app	(A → B)	nm s^-1	2	4	5	310	12
P_app	(B → A)	nm s^-1	3	6	240	410	470
Efflux ratio (B → A/A → B)			1.5	1.5	48	1.3	38

A = apical, B = basolateral. Experiments performed in duplicate (n = 2).

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