Skip to main content

Table 3 Mean permeation rates and efflux ratios in LLC-PK1-MDR1 cell monolayers

From: Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

  Nor-BNI GNTI JDTic Naltrexone Loperamide
Papp (A → B) nm s-1 2 4 5 310 12
Papp (B → A) nm s-1 3 6 240 410 470
Efflux ratio (B → A/A → B) 1.5 1.5 48 1.3 38
  1. A = apical, B = basolateral. Experiments performed in duplicate (n = 2).