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Figure 1 | BMC Pharmacology

Figure 1

From: Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors

Figure 1

Effects of active linaclotide and lubiprostone on (A) change in transepithelial electrical resistance (ΔTER), (B) paracellular flux (Jm-s) of3H-mannitol, (C) Western analysis of occludin and (D) Δ Isc in normal and ischemic pig jejunum. In (A) and (B) data is plotted as mean ± S.E. (A) ΔTER: n = 5; *p < 0.01, **p < 0.005, #p < 0.05 and NS, not significant all wrt control. (B) 3H-mannitol Jm-s: n = 3; *p < 0.05, #p < 0.02 and NS, not significant wrt ischemic control; **p < 0.02 ischemia control vs non-ischemic control. (C) Western analysis: example of n = 3 experiments. Lanes 1–3, Tx-100 insoluble fractions; lanes 4–8, detergent-soluble fractions; last lane, whole lysate (lys). (D) Δ Isc: n = 4; control intestine: *p < 0.025, # p < 0.005 wrt control and Δlin vs Δlubi are NS, not significant; ischemic intestine: ** p < 0.025 wrt lin, ## p < 0.005 wrt ischemic control, NS, not significant wrt ischemic control.

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BMC Pharmacology

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