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Table 2 Inhibition of isolated, cloned human DPP4, DPP8 and DPP9 at 37°C

From: Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor

  DPP4 Ki (nM) DPP8 Ki (nM) DPP9 Ki (nM)
Saxagliptin 1.3 ± 0.3 (12) 508 ± 174 (13) 98 ± 44 (11)
5-hydroxysaxagliptin 2.6 ± 1.0 (12)*** 2495 ± 727 (14)* 423 ± 64 (12)
Vildagliptin 13 ± 2.8 (12)*** 5218 ± 2319 (14)*** 258 ± 93 (12)
Sitagliptin 18 ± 1.6 (12)*** 33780 ± 5532 (12)*** 55142 ± 19414 (11)***
  1. mean ± standard deviation (number of independent experiments). *P < 0.05, **P < 0.01, ***P < 0.001 versus saxagliptin