From: Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor
compound
GLP-1 Ki (nM)
gly-pro-pNA Ki (nM)
Saxagliptin
0.41 ± 0.1 (7)
0.45 ± 0.1 (5)
Sitagliptin
2.5 ± 0.7 (4) ***
8 ± 1 (5)***
Vildagliptin
1.5 ± 0.5 (4) ***
7 ± 2 (5)***