Skip to main content
Figure 4 | BMC Pharmacology

Figure 4

From: Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor

Figure 4

The effect of pseudo-substrate choice on the measurement of plasma DPP activity ex vivo in cynomolgus monkeys 24 hours post dose. **P < 0.01, ***P < 0.001 versus vehicle. †P < 0.05, ††P < 0.01, versus ala-pro-AFC at the same dose. The dashed line represents the average maximum inhibition seen (68.9 ± 3.9%, 1 hour post dose at the highest doses tested).

Back to article page

BMC Pharmacology

ISSN: 1471-2210