BMC Pharmacology

Table 1 LogEC₅₀ and E_max values for the activation of RIα (a), RIIα (b) and PKGIα (c) with cNMPs

From: Activation of cGMP-dependent protein kinase Iα and cAMP-dependent protein kinase A isoforms by cyclic nucleotides

A
	cAMP	cIMP	cGMP	cCMP	cUMP	cXMP
LogEC₅₀[M]	-7.1	-5.9	-4.9	-4.4	-4.2	-3.5
E_max	1.00	1.09	1.06	1.04	1.04	1.00
B
	cAMP	cIMP	cGMP	cCMP	cUMP	cXMP
LogEC₅₀[M]	-7.0	-5.4	-4.5	-4.0	-4.4	-3.2
E_max	1.00	1.07	1.07	1.23	1.26	1.07
C
	cGMP	cAMP	cCMP	cUMP
LogEC₅₀ [M]	-7.0	-5.0	-4.9	-4.1
E_max	1.00	0.46	0.56	0.71

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