Table 1 Comparison of ExoY with CyaA and EF
Parameter | ExoY | CyaA | EF |
|---|---|---|---|
Bacterial source | Pseudomonas aeruginosa | Bordetella pertussis | Bacillus anthracis |
Secretion type | III | I | II |
Function as toxin | Unknown, “antitoxin?” | yes | yes |
Activation mechanism | Cytosolic cofactor (mammalian cells and D. discoideum) | calmodulin | calmodulin |
Substrate-specificity purified enzyme | GTP >> UTP ≥ ATP > CTP | ATP >> CTP > UTP > GTP | ATP >> CTP > UTP > GTP |
Substrate-specificity intact cells | UTP ~ GTP > ATP > CTP (except for B103 cells) | ATP >> CTP > UTP >> GTP (ineffective) | ATP >> CTP >> UTP and GTP(ineffective) |