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Table 1 Pharmacokinetic parameters of CIN in healthy controls and individuals with mild, moderate and severe renal impairment, showing values as geometric mean (coefficient of variation, %) except for fu which is expressed as arithmetic mean (standard deviation).

From: Pharmacokinetic analysis of the soluble guanylate cyclase activator cinaciguat (BAY 58-2667) in individuals with renal impairment compared to healthy controls

Renal function group

CL (L/h)

Vss (L)

t½ (h)

fu %

Group 1: Healthy control (n=9)

36.12 (12.3)

18.70 (19.2)

1.56 (53.4%)

0.45 (0.12)

Group 2: Mild renal impairment (n=8)

41.43 (15.3)

26.56 (37.6)

1.72 (65.1%)

0.42 (0.07)

Group 3: Moderate renal impairment (n=9)

40.58 (18.9)

24.02 (27.1)

1.58 (49.6%)

0.53 (0.15)

Group 4: Severe renal impairment (n=8)

51.81 (26.2)

23.51 (18.7)

1.08 (64.0%)

0.66 (0.16)