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Table 1

From: Inhaled and intravenous application of a stimulator of the soluble guanylate cyclase (BAY 41-8543) reduces pulmonary vascular resistance in a model of septic shock

 

shock

(n=32)

i.h.

(n=12)

i.v.

(n=14)

con

(n=6)

i.h. D2

(n=6)

i.h. no

(n=5)

i.v. D2

(n=5)

i.v. no

(n=5)

con no

(n=5)

HR

127

(34)

150

(21)

163**

(28)

123

(34)

140

(35)

146

(19)

171

(29)

148

(29)

113

(34)

MAP

58

(7)

71

(7)

68

(6)

73

(8)

75

(6)

69

(9)

68

(14)

73

(10)

73

(8)

MPAP

38

(7)

40

(7)

37

(8)

44

(6)

42

(10)

42

(9)

40

(16)

37**

(9)

39**

(9)

PVR

1246

(401)

491**

(106)

469**

(198)

972

(325)

691**

(322)

573**

(245)

849*

(815)

460**

(103)

887**

(296)

CO

2.02

(0.51)

4.65**

(0.76)

5.04**

(1.43)

2.93

(0.89)

3.73

(1.71)

4.16*

(1.44)

4.3**

(2.85)

4.06**

(0.78)

2.46

(0.67)

  1. * p<0.05   **p<0.01   vs. control group (con)