Figure 1From: Molecular aspects of sGC regulationSchematic of sGC regulation by NO. In the resting, unliganded state, sGC has a low basal activity. The addition of NO leads initially to a 6-coordinate complex that then forms a highly active 5-coordinate complex. Evidence supports an additional requirement for NO that accelerates the formation of the 5-coordinate complex and fully activates the enzyme.Back to article page