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Figure 4 | BMC Pharmacology

Figure 4

From: Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo

Figure 4

Apoptosis induction by GO-Y030, 078, and 098. (a) FACS analysis. Percentage of cells cycling in each phase, G0/G1, S, and G2/M including subG1 is represented in the column. (b) Effect on caspase induction. Caspase cleavage reaction was assessed by the relative expression of cleaved cytokeratin 18 against the control (= 1.0). (c) Effects on NF-κB transactivation. The relative amount of NF-κB p50 subunit binding its target DNA element, treated with 2 μM analogs in SW620 is indicated, compared to treated controls (TNFα alone, = 1.0). (d) Effects of 2 μM analogs on TP53 expression. The relative amount of TP53 is represented against the control (= 1.0). (e) Effects on DR5 expression. Relative expression value against the control (= 1.0) is represented at the bottom. β-actin is labeled as ACTB, and curcumin labeled as Cur.

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