Figure 3

Solubility of curcumin analogs. (a) in silico prediction of solubility. The blue bar indicates analog belonging to Group a in Figure 2, and the red indicates Group b. The analogs labeled gray were not analyzed in Figure 2. (b) Chemical structure of DOPs bearing the lowest IC₅₀ value and higher solubility. The methoxy group is indicated as MeO, and the methoxymethoxy group indicated as MOMO. (c) Appearance of the diluted solution of curcuminoids. Curcumin and its analogs were dissolved in ethanol-cremophor EL^® at nearly the maximum concentration denoted in each column, then diluted serially with PBS. The dilution ratio is depicted at the top of each column. Aggregation is labeled as Agg.