Figure 4

RNA editing profiles of 5-HT _2C R mRNA in amygdala of SERT +/+ and -/- mice. 4A. 5-HT_2CR RNA editing per site. Compared to SERT +/+ mice, SERT -/- mice had significant increases in the editing rate of sites A, B and D, with no differences in editing rates for sites C or E. 4B. Frequency of 5-HT_2CR isoforms. Compared to SERT +/+ mice, SERT -/- mice evidenced a decrease in the expression of the non-edited, D and BD isoforms, and an increase in the ABD and ABCD isoforms. Data represent the mean ± SEM, 4 animals per group. *** p < 0.001, ** p < 0.01 and * p < 0.05 significantly different from SERT +/+ mice.