Skip to main content
Figure 3 | BMC Pharmacology

Figure 3

From: Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice

Figure 3

Effects of RO 60-0175 in the open field test in SERT +/+ and -/- mice. 3A. Effects of RO 60-0175 on anxiety-like behavior. SERT +/+ and SERT -/- mice were given vehicle or RO 60-0175 4 mg/kg ip 30 min prior to testing. RO 60-0175 increased anxiety-like behavior (decreased visits to the center) in the open field in SERT +/+ mice, with no effect in SERT -/- mice. 3B. Effects of RO 60-0175 on locomotor activity. RO 60-0175 4 mg/kg ip administered 30 min prior to testing decreased the total distance traveled in SERT +/+ mice compared to vehicle, with no effects in SERT -/- mice. Data represent the mean ± SEM, 9-10 animals per group. **** p < 0.0001 vs. SERT +/+ mice in the same drug condition; ++ p < 0.01 and + p < 0.05 vs. mice of the same genotype administered vehicle.

Back to article page

BMC Pharmacology

ISSN: 1471-2210