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Figure 2 | BMC Pharmacology

Figure 2

From: Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice

Figure 2

Effects of pretreatment with the selective 5-HT 2C antagonist RS 102221 on the anxiogenic effects of mCPP on "sociability" in the social interaction test in wildtype C57BL/6J mice. Mice were given vehicle or RS 102221 1 mg/kg ip 15 min prior to vehicle or mCPP 1 mg/kg ip. RS 102221 antagonized the anxiogenic effects of mCPP on "sociability." Data represent the mean ± SEM, 5-7 animals per group. **** p < 0.0001 and ** p < 0.01 vs. the stranger chamber in mice of the same genotype in the same drug condition; N.S. not significant.

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