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Figure 1 | BMC Pharmacology

Figure 1

From: Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice

Figure 1

Effects of mCPP in the social interaction test in SERT +/+ and -/- mice. 1A. Effects of mCPP on "sociability". SERT +/+ and -/- mice were given vehicle or mCPP 1 mg/kg ip 30 min prior to testing. mCPP decreased sociability (indicating increased anxiety) in SERT +/+ mice, with no effects in SERT -/- mice. 1B . Effects of mCPP on "sniffing." SERT +/+ and SERT -/- mice were given vehicle or mCPP 1 mg/kg ip 30 min prior to testing. mCPP decreased sniffing in SERT +/+ mice (indicating increased anxiety), with no effects in SERT -/- mice. 1C. Effects of mCPP on locomotor activity. There was no effect of mCPP 1 mg/kg ip administered 30 min prior to testing on the number of entries into the different chambers. Data represent the mean ± SEM, 7 animals per group. *** p < 0.001, ** p < 0.01, and * p < 0.05 vs. the stranger chamber in mice of the same genotype in the same drug condition; +++ p < 0.01 vs. mice of the same genotype given vehicle; N.S. not significant.

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BMC Pharmacology

ISSN: 1471-2210