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Table 2 Amplitudes of population spike

From: Effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro

 

Single Stimulus

Theta Burst Stimulus

 

μV

μV

RS-ATPA 0.05 μM

-1904.2 ± 55.4

-3054.5 ± 42.2

+ Rasagiline 5.00 μM

-1789.0 ± 54.6 n.s

-2998.5 ± 108.3 n.s

+ Aminoindan 5.00 μM

-1946.1 ± 58.8 n.s

-2850.8 ± 92.1 n.s

+ Selegiline 2.50 μM

-1616.1 ± 37.8 p < 0.01

-2531.3 ± 136.4 p < 0.01

+ Selegiline 5.00 μM

-1256.7 ± 53.2 p < 0.01

-2133.6 ± 48.4 p < 0.01

  1. Effect of selegiline on Kainate receptor dependent increase of population spike amplitude, but lack of effect by rasagiline or aminoindan. Values are given as mean of n = 4 slices +- S.E.M. Statistical significance to ATPA signal is given as p-value.
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BMC Pharmacology

ISSN: 1471-2210