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Figure 5 | BMC Pharmacology

Figure 5

From: Effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro

Figure 5

Concentration dependent effects of rasagiline, aminoindan and selegiline in the presence of single stimuli (SS) or theta burst stimuli (TBS) after stimulation of the AMPA glutamate receptor by fluorowillardiine (n = 4 slices +- SEM). Statistically significant attenuation of pop-spike amplitude in comparison to fluorowillardiine-induced increases were obtained in the presence of 1 μM of rasagiline or aminoindan following single stimuli (SS). During theta burst stimulation (TBS) already a concentration of 1 μM of rasagiline or aminoindan became statistically significant. Stars indicate statistical significance of p < 0.05 in comparison to control.

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BMC Pharmacology

ISSN: 1471-2210