Skip to main content

Table 2 Skin permeation parameters

From: The effect of formulation vehicles on the in vitro percutaneous permeation of ibuprofen

Formulation

Recovery (%)

Jmax (Ī¼ g/cm2/h)

Lagtime (h)

Skin absorption (Ī¼ g/cm2)

Ibutop Ā® gel

21 Ā± 5a

50 Ā± 23

0.0 Ā± 0.2ac

239 Ā± 159

Ibutop Ā® cream

59 Ā± 8

65 Ā± 15

1.3 Ā± 0.6

57 Ā± 25

Ibuprofen solution

26 Ā± 8b

42 Ā± 16

1.3 Ā± 0.8

264 Ā± 192

  1. Absorption parameters of bovine udder skin (recovery in the receptor chamber, Jmax, lagtime, and skin absorption) following application of different topical formulations containing ibuprofen 5%; n = 5-6, mean and standard deviation; p < 0.05 (One-way ANOVA followed by Tukey's multiple comparison test; a: gel vs. cream, b: solution vs. cream, c: gel vs. solution)
Back to article page

BMC Pharmacology

ISSN: 1471-2210