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Table 2 Skin permeation parameters

From: The effect of formulation vehicles on the in vitro percutaneous permeation of ibuprofen

Formulation Recovery (%) Jmax (μ g/cm2/h) Lagtime (h) Skin absorption (μ g/cm2)
Ibutop ® gel 21 ± 5a 50 ± 23 0.0 ± 0.2ac 239 ± 159
Ibutop ® cream 59 ± 8 65 ± 15 1.3 ± 0.6 57 ± 25
Ibuprofen solution 26 ± 8b 42 ± 16 1.3 ± 0.8 264 ± 192
  1. Absorption parameters of bovine udder skin (recovery in the receptor chamber, Jmax, lagtime, and skin absorption) following application of different topical formulations containing ibuprofen 5%; n = 5-6, mean and standard deviation; p < 0.05 (One-way ANOVA followed by Tukey's multiple comparison test; a: gel vs. cream, b: solution vs. cream, c: gel vs. solution)