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Table 1 Binding affinities calculated from radiologand ([125I]I-AB-MECA) binding experiments.

From: Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A3 adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts

Agonist mA3AR,
Ki or Kiapp (nM)
mA1AR,
Ki or Kiapp (nM)
Selectivity (A1 /A3)
MRS5246 0.04 ± 0.002 14.35 ± 4.35 359-fold
MRS5233 3.94 ± 0.31 665 ± 70 169-fold
  98.5-fold increase
(MRS5233/MRS5246)
46.3-fold increase
(MRS5233/MRS5246)