Table 1 Binding affinities calculated from radiologand ([125I]I-AB-MECA) binding experiments.
Agonist | mA3AR, Ki or Kiapp (nM) | mA1AR, Ki or Kiapp (nM) | Selectivity (A1 /A3) |
|---|---|---|---|
MRS5246 | 0.04 ± 0.002 | 14.35 ± 4.35 | 359-fold |
MRS5233 | 3.94 ± 0.31 | 665 ± 70 | 169-fold |
| Â | 98.5-fold increase (MRS5233/MRS5246) | 46.3-fold increase (MRS5233/MRS5246) | Â |