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Figure 6 | BMC Pharmacology

Figure 6

From: Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A3 adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts

Figure 6

The GLiDe conjugate, MRS5246, was effective at increasing functional recovery of isolated mouse hearts after 20 min ischemia/45 min reperfusion compared to control at 0.1 (A), 1 (B), and 10 nM (C). Both 1 and 10 nM concentrations of MRS5246 evoked significant improvement of LVDP over control during reperfusion. The insets show that there was also significantly better recovery of rates of relaxation and contraction at 45 min reperfusion than that of control hearts at both concentrations.

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BMC Pharmacology

ISSN: 1471-2210