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Figure 5 | BMC Pharmacology

Figure 5

From: Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A3 adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts

Figure 5

The monomeric analogue, MRS5233, was effective at increasing functional recovery of isolated mouse hearts after 20 min ischemia/45 min reperfusion compared to control at 1 (A) and 10 nM (B). 1 nM MRS5233 showed a trend in improving LVDP over control during reperfusion, while there was significant improvement with 10 nM MRS5233. The insets show that the recovery of rates of relaxation and contraction at 45 min reperfusion was significantly better than that of control hearts at both concentrations.

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BMC Pharmacology

ISSN: 1471-2210