Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice

Table 4 Protease-activated receptor 2, cyclooxygenase-1 and cyclooxygenase-2 mRNA expression in angiotensin II- and saline-treated mice.

mRNA	Ratio (angiotensin II to saline)
	normalised to triad		normalised to par2
protease-activated receptor 2	0.6	0.2-1.8
cyclooxygenase-1	1.5	0.5-4.5	2.4^b	1.2-4.2
cyclooxygenase-2	2.9^a	0.6-16	4.5^c	0.9-26

mRNA expression in mesenteric arterial cascades from mice was determined by real-time PCR and normalised to triad housekeeping, and to protease-activated receptor 2 genes (par2).
angiotensin II (ANG II) C57, n = 12; saline C57, n = 11.
Values reported are the mean and SE range (mean minus lower SE and mean plus upper SE).
^aP < 0.05, ^bP < 0.001, ^cP < 0.0005, gene upregulated in ANG II C57 compared with saline C57. See Methods for details of statistical analyses.