Figure 2

Inhibition of PAR2 agonist-induced vasodilations in ANG II C57 by pretreatment with SK3.1 inhibitor. C57BL/6J (C57) mice were pretreated with angiotensin II (ANG II) for two weeks prior to experiments. Values are the mean ± SE (n = number of mice) for 2-furoyl-LIGRLO-amide 2fly-induced relaxations of ANG II C57 second order mesenteric arteries contracted submaximally by cirazoline. Arteries were exposed to inhibitors [10 μM TRAM-34, 100 μM L-NAME + 10 μM TRAM-34] for 20 min prior to cirazoline. *P < 0.05, E_max, 10 μM TRAM-34 and 100 μM L-NAME + 10 μM TRAM-34 compared to untreated (control) arteries, one-way ANOVA followed by Bonferroni post hoc test. **P > 0.05, L-NAME + TRAM-34, relaxations at each dose of 2fly compared to 0, one-sample t-test.