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Figure 4 | BMC Pharmacology

Figure 4

From: Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) Receptor Antagonist

Figure 4

Effect of CE-178253 in fast-induced refeeding food intake model. 4A. Dose- and time-dependent effects on cumulative FI in S-D rats by oral administered CE-178253 in the fast-induced refeeding model. Overnight fasted S-D rats were given veh. (0.5% MC) or 0.3 mg/kg, 1 mg/kg, 3 mg/kg, or 10 mg/kg CE-178253 p.o. in 0.5% MC. Food was returned 30 min after dosing and cumulative food consumption was measured at the 2 hr time point. The number of animals was 8-11 in the veh. and CE-178253 treated groups. Veh.-treated rats ate 8.2 ± 0.3 grams chow. The reduction in FI ± SEM in grams/rat is displayed. * = p < 0.05 vs. veh. 4B. concentration-effect relationship for CE-178253 in the fasted-induced refeeding FI model. The unbound plasma concentration of CE-178253 was measured at 2.5 hr post-dose. The EC50 corresponds to a 35% reduction at two hr post-dose which corresponds to a maximal FI reduction of 70% in this model.

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