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Table 1 Performance of SVM models developed for different CYP isoforms, all models evaluated using fivefold cross-validation technique

From: Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule

Isoforms POE* NEE** Sensitivity Specificity Accuracy (%) MCC
CYP3A4 111 105 81.08 81.74 81.42 0.63
CYP2D6 47 169 74.47 83.24 81.24 0.54
CYP1A2 29 187 79.31 83.76 83.19 0.49
CYP2C9 20 196 70.00 85.92 84.51 0.40
CYP2C19 19 197 52.63 72.46 70.80 0.15
  1. POE*: Positive Examples
  2. NEE**: Negative Examples
  3. Thres*: Threshold (Cutoff Value)