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Table 1 Performance of SVM models developed for different CYP isoforms, all models evaluated using fivefold cross-validation technique

From: Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule

Isoforms

POE*

NEE**

Sensitivity

Specificity

Accuracy (%)

MCC

CYP3A4

111

105

81.08

81.74

81.42

0.63

CYP2D6

47

169

74.47

83.24

81.24

0.54

CYP1A2

29

187

79.31

83.76

83.19

0.49

CYP2C9

20

196

70.00

85.92

84.51

0.40

CYP2C19

19

197

52.63

72.46

70.80

0.15

  1. POE*: Positive Examples
  2. NEE**: Negative Examples
  3. Thres*: Threshold (Cutoff Value)