Promiscuous modulation of ligand-gated ion channels. The four members of the cys-loop family of ligand gated ion channels are shown as black nodes. Endogenous and exogenous modulators exhibiting electrophysiologically confirmed modulation of one or more of these channel classes are indicated by a blue line connecting the modulator to the receptor(s). Modulators in the four corners are those showing documented modulation of only one channel class, while those centrally located modulate all four classes. Endog, endogenous; AA, amion acids; misc, miscellaneous; anesth, anesthetics; AED, anti-epileptic drug; psych, psychiatric. This figure was generated using Cytoscape software.