Figure 4

Lack of effect of DA receptor antagonists on the inhibition of mitochondrial ROS generation induced by pramipexole (PPX) enantiomers. Cells were exposed to 10 μM S(-) PPX (gray bars) and R(+) PPX (white bars) for 1 h in the absence or presence of 10 μM haloperidol (H) or 10 μM (-) sulpiride (S) before being exposed to laser. Mitochondrial ROS generation was evaluated as in figure 2. Data represent means ± SEM of at least three different experiments and are from three separate cell preparations. *, p < 0.01 vs the corresponding control values (black bars).