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Table 5 Induction of antiviral activity in serum.

From: Pharmacokinetic and pharmacodynamic comparison of two "pegylated" interferon alpha-2 formulations in healthy male volunteers: a randomized, crossover, double-blind study

Time

Formulation A N = 15

Formulation B N = 15

Wilcoxon's paired test between formulations

Baseline activity in serum

0.0 ± 1.0 (0.0; 2.5)

1.0 ± 2.0(0.0; 4.0)

p = 0.187

Activity in serum at Tmax

16.0 ± 32.0(4.0; 73.0)

20.0 ± 20.0(0.0; 59.0)

p = 0.513

Wilcoxon's paired test between times

p = 0.001

p = 0.001

 
  1. Antiviral titers are expressed in IU/mL. Data are reported as median ± quartile range (range). One volunteer (#13) was excluded from this comparison
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BMC Pharmacology

ISSN: 1471-2210