Table 1 Mean ± SE serum biomarker concentration for each of the study arms.
Group | Dose (mg/kg) | AST | ALT | BUN | Creatinine | |
|---|---|---|---|---|---|---|
| Â | SUN | PCM | (U/L) | (U/L) | (mg/dL) | (mg/dL) |
Vehicle | - | - | 160.4 ± 24.7 | 14.29 ± 2.31 | 15.6 ± 2.17 | 0.529 ± 0.044 |
PCM | - | 500 | 377.1 ± 173.6 | 249.6 ± 222.7 | 33.81 ± 5.68 | 0.644 ± 0.110 |
Sunitinib | 25 | - | 204.6 ± 50.3 | 61.40 ± 26.57 | 20.08 ± 2.54 | 0.535 ± 0.033 |
|  | 50 | - | 204.4 ± 49.4 | 36.75 ± 12.15 | 17.5 ± 1.25 | 0.594 ± 0.082 |
|  | 80 | - | 290.3 ± 77.7 | 75.02 ± 20.37 | 19.71 ± 0.58 | 0.528 ± 0.064 |
|  | 100 | - | 243.0 ± 66.4 | 47.61 ± 24.50 | 17.62 ± 0.94 | 0.533 ± 0.060 |
|  | 140 | - | 239.5 ± 65.9 | 50.89 ± 18.90 | 26.68 ± 6.05 | 0.559 ± 0.051 |
Sunitinib | 25 | 500 | 259.7 ± 67.4+ | 182.8 ± 64.91* | 38.24 ± 6.08* | 0.514 ± 0.089 |
& PCM | 50 | 500 | 264.4 ± 104.9 | 186.7 ± 124.3 | 38.89 ± 8.69* | 0.520 ± 0.143 |
|  | 80 | 500 | 430.2 ± 163.6 | 221.0 ± 113.0 | 35.01 ± 6.95* | 0.591 ± 0.084 |
|  | 100 | 500 | 469.8 ± 90.3+* | 349.2 ± 132.4* | 43.75 ± 8.37* | 0.502 ± 0.103 |
|  | 140 | 500 | 540.3 ± 76.1+* | 269.6 ± 72.6* | 52.85 ± 12.53+* | 0.627 ± 0.060 |