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Figure 9 | BMC Pharmacology

Figure 9

From: Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice

Figure 9

Photomicrographs of representative histopathological changes in heart tissue (H&E staining). Photomicrographs of kidney tissue sections after administration of sunitinib or sunitinib and paracetamol. A: photomicrograph (100x) from heart tissue from the control saline group showing the ventricular wall with normal orientation of healthy cardiomyocytes. B: photomicrograph (200x) from the saline vehicle group showing the normal morphology of the muscle fibers with abundant wavy cytoplasm and small nuclei. C: photomicrograph (200x) after administration of paracetamol showing numerous congested vessels (arrows) amidst the muscle fibres. D: photomicrograph (200x) showing congested and dilated blood vessels (arrows) in the heart muscle filled with red blood cells after administration of 50 mg/kg sunitinib. E: photomicrograph (200x) showing congested and dilated blood vessels in the heart muscle after coadministration of 80 mg/kg sunitinib with paracetamol. F: photomicrograph (200x) showing further congested and dilated blood vessels in the heart muscle and filled with red blood cells after coadministration of sunitinib (100 mg/kg) and paracetamol.

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