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Figure 7 | BMC Pharmacology

Figure 7

From: Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice

Figure 7

Representative histopathological changes in kidney after administration of sunitinib alone or coadministered with paracetamol (H&E staining). Photomicrographs of kidney tissue sections after administration of sunitinib or sunitinib and paracetamol. A: (200x) photomicrograph after administration of sunitinib (50 mg/kg) showing glomeruli atrophy (yellow arrow). Notice the reduction in size and cellularity, when compared to normal glomeruli (blue arrow). B: photomicrograph (100x) after administration of sunitinib (80 mg/kg) showing glomerular atrophy admixed with congested spaces and extravasated red blood cells in the interstitium. C: photomicrograph (200x) after coadministration of sunitinib (140 mg/kg) and paracetamol, showing tubules filled with casts in the lumen (arrow).

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