Figure 4
Histopathological changes in liver after coadministration of sunitinib and paracetamol (H&E staining). Photomicrographs of liver sections after coadministration of sunitinib (25 mg/kg) and paracetamol. A: (200x) damaged hepatocytes with areas of fatty change (arrows), sinusoid congestion and central vein dilation. B: (400x) red blood cells accumulated around the draining pathways of the central vein (arrow) suggesting backflow congestion. C: fatty change in the cytoplasm and pyknotic nuclei (arrows). D: photomicrograph (200x) after combination treatment of sunitinib 50 mg/kg and paracetamol showing a focal area of microabscess (circle) consisting of inflammatory cells and necrotic debris.