Figure 11
Photomicrographs of representative histopathological changes in brain tissue (H&E staining, 100x). Photomicrographs of representative brain regions after administration of sunitinib or combination treatment of sunitinib and paracetamol. A: photomicrograph showing zones of congested blood vessels of moderate to small size (arrows) bordering the cellular areas after administration of sunitinib 50 mg/kg dose. B: photomicrograph from the sunitinib 80 mg/kg group showing vascular congestion in the brain. C: photomicrograph from the combination treatment sunitinib (50 mg/kg) and paracetamol group showing vascular congestion (arrows) in the brain. D: photomicrograph showing vascular congestion in the brain after coadministration of sunitinib 100 mg/kg and paracetamol.