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Table 2 Inhibitory concentrations 50% (IC50) and maximal inhibition of cell growth of different breast and prostate cancer cell lines by receptorphin.

From: Receptorphin: A conserved peptide derived from the sequence of the opioid receptor, with opioid displacement activity and potent antiproliferative actions in tumor cells

 

Receptorphin

Maximum Inhibition

Receptorphin+ Diprenorphin

Maximum Inhibition

MCF7

1.51 ± 0.18 × 10-10

0.41

1.69 ± 0.10 × 10-9

0.49

T47D

7.01 ± 0.36 × 10-11

0.44

3.61 ± 0.13 × 10-9

0.48

LNCaP

8.70 ± 0.87 × 10-8

0.58

2.88 ± 0.15 × 10-9

0.61

DU145

4.36 ± 0.19 × 10-10

0.59

3.44 ± 2.32 × 10-7

0.53

PC3

6.98 ± 0.11 × 10-9

0.27

7.00 ± 0.14 × 10-7

0.31

  1. Curves were obtained by sigmoidal fitting of data presented in Figure 2. Concentrations are expressed in Moles/L. Mean ± SE of three different experiments performed in triplicate.
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BMC Pharmacology

ISSN: 1471-2210