Skip to main content

Table 3 Effect of T. avellanedae aqueous extract (AE, 100, 200, and 400 mg/Kg) and morphine at the formalin 1% test. The results of the AE at the analgesia model induced by formalin are shown as the median of the time, which each mouse spent licking its posterior left paw after administration of formalin (1%) and its respective percentage. The AE (200 and 400 mg/Kg) significantly reduced the second phase of the formalin test.

From: Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract

  

1st phase

2nd phase

Treatment

Dose (mg/Kg)

Median

%

Median

%

Control

-

58.5

-

36

-

Morphine (i.p.)

7.5

10.5a

87

0a

81.8

AE (p.o.)

100

45

38

16

28.5

AE (p.o.)

200

43

43.1

6a

49.3

AE (p.o.)

400

38

43.1

1a

53.7

Morphine (i.p.)+Naloxone (i.p.)

5

55.5

16.5

18a

33.8

Naloxone (i.p.)+AE400

5

37a

62.8

3a

71.4

Caffeine (i.p.)+AE400

10

44a

55

26.5

19.8

  1. %, pain reaction time inhibition percentage. ap < 0.05 compared to control (Kruskal-Wallis, followed by Nemenyi), AE400, aqueous extract 400 mg/Kg.