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Table 3 Effect of T. avellanedae aqueous extract (AE, 100, 200, and 400 mg/Kg) and morphine at the formalin 1% test. The results of the AE at the analgesia model induced by formalin are shown as the median of the time, which each mouse spent licking its posterior left paw after administration of formalin (1%) and its respective percentage. The AE (200 and 400 mg/Kg) significantly reduced the second phase of the formalin test.

From: Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract

   1st phase 2nd phase
Treatment Dose (mg/Kg) Median % Median %
Control - 58.5 - 36 -
Morphine (i.p.) 7.5 10.5a 87 0a 81.8
AE (p.o.) 100 45 38 16 28.5
AE (p.o.) 200 43 43.1 6a 49.3
AE (p.o.) 400 38 43.1 1a 53.7
Morphine (i.p.)+Naloxone (i.p.) 5 55.5 16.5 18a 33.8
Naloxone (i.p.)+AE400 5 37a 62.8 3a 71.4
Caffeine (i.p.)+AE400 10 44a 55 26.5 19.8
  1. %, pain reaction time inhibition percentage. ap < 0.05 compared to control (Kruskal-Wallis, followed by Nemenyi), AE400, aqueous extract 400 mg/Kg.